Case Report: Diagnosis of Primary Cutaneous Amyloidosis Using Dermoscopy and Reflectance Confocal Microscopy

Frontiers in Medicine

Ze Guo¹  Zhenyu Zhong¹  Yifan Wang¹  Hui Li¹  Min Gao¹  Xiuli Wang¹  Liyun Zheng¹  Hui Wang¹ 

[1] Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China;

关键词: primary cutaneous amyloidosis;    dermoscopy;    reflectance confocal microscopy;    non-invasive technique;    diagnosis;   

DOI  :  10.3389/fmed.2020.619907

来源: Frontiers

【 摘 要 】

The dermoscopy and reflectance confocal microscopy (RCM) can provide new insights for diagnosis disease as non-invasive and easy-to-use tool. We described the dermoscopy and RCM characteristics of two patients with primary cutaneous amyloidosis (PCA) respectively. The dermoscopy characteristics were as follows: brownish macules with brown or white centers surrounded by hyperpigmented blotches, and a whitish scar-like center encircled by irregular brownish hyperpigmented spots or patches. The RCM features were increased melanin deposition in the basal layer, highly refractive structures with various shapes in the enlarged papillary dermis, and the increased pleomorphic structure of the dermal papillary ring. This is the first report the dermoscopy and RCM characteristics of PCA. We hope the characteristic dermoscopy and RCM appearances would provide a basis for doctors to diagnose and intervene earlier.

【 授权许可】

CC BY