QseC Inhibition as a Novel Antivirulence Strategy for the Prevention of Acute Hepatopancreatic Necrosis Disease (AHPND)-Causing Vibrio parahaemolyticus

Frontiers in Cellular and Infection Microbiology

Songzhe Fu¹  Qingyao Wang¹  Peizhuo Zou²  Guosi Xie²  Zhi Cao²  Qian Yang³  Jie Huang⁴ 

[1] College of Marine Science and Environment, Dalian Ocean University, Dalian, China;Key Laboratory of Environment Controlled Aquaculture (KLECA), Ministry of Education, Dalian, China;Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China;Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao, China;Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China;Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China;Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao, China;Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China;Center for Microbial Ecology and Technology (CMET), Ghent University, Gent, Belgium;Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China;Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Qingdao, China;Qingdao Key Laboratory of Mariculture Epidemiology and Biosecurity, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, China;Network of Aquaculture Centers in Asia-Pacific, Bangkok, Thailand;

关键词: acute hepatopancreatic necrosis disease;    Vibrio parahaemolyticus;    antivirulence therapy;    QseC;    LED209;   

DOI  :  10.3389/fcimb.2020.594652

来源: Frontiers

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