Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease

Frontiers in Medicine

Daniela Montorio¹  Chiara Comune¹  Maria Paola Laezza¹  Matteo Fallico²  Maria Elena Lionetti³  Gilda Cennamo⁴  Michele Reibaldi⁵ 

[1]Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy

[2]Department of Ophthalmology, University of Catania, Catania, Italy

[3]Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy

[4]Department of Public Health, University of Naples Federico II, Naples, Italy

[5]Department of Surgical Sciences, University of Torino, Turin, Italy

关键词: SD-OCT;    OCTA;    Coats disease;    anti-VEGF injections;    retinal vascular features;   

DOI  :  10.3389/fmed.2020.615015

来源: Frontiers

【 摘 要 】

The aim of this retrospective study was to describe the vascular features in eyes with Coats disease, using optical coherence tomography angiography (OCTA), at baseline and after 3 monthly intravitreal injections of ranibizumab. Fifteen eyes of 15 consecutive patients affected by Coats' disease were recruited in this study. All patients underwent the best-corrected visual acuity (BCVA) evaluation, fundus examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), multicolor imaging, structural Spectral Domain (SD)-OCT and OCTA at baseline and 1 month after the third monthly ranibizumab injection (loading phase). Fifteen patients completed the study, of whom nine were males and six females. Mean age was 20.4 ± 2 years. BCVA was 0.46 ± 0.11 logMar and 0.47 ± 0.12 logMar at baseline and after treatment, respectively (p = 0.164). SD-OCT revealed no significant decrease in central macular thickness (486.33 μm ± 93.37 at baseline vs. 483.4 μm ± 80.97 after treatment; p = 0.915). The subretinal exudates persisted in macular region after intravitreal injections. OCTA showed a general vascular rarefaction in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary (CC) that did not change after loading phase. This study showed no functional and vascular improvement following 3 monthly ranibizumab injections. OCTA, non-invasive technique, could be useful during follow up of these patients and provide a better understand of pathogenesis of this disorder.

【 授权许可】

CC BY