Surface modification of poly(dimethylsiloxane) and its applications in microfluidics-based biological analysis

Reviews in analytical chemistry

article

Qin Tu¹  Jinyi Wang¹  Jian-Chun Wang¹  Yanrong Zhang¹  Rui Liu¹  Wenming Liu¹  Li Ren²  Shaofei Shen¹  Juan Xu¹  Lei Zhao² 

[1] College of Science, Northwest A&F University;College of Veterinary Medicine, Northwest A&F University

关键词: biological analysis;    microfluidic device;    poly(dimethylsiloxane);    surface modification;   

DOI  :  10.1515/revac-2012-0016

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Poly(dimethylsiloxane) (PDMS)-based microfluidic systems have been gaining popularity in various applications, particularly for biological analyses because of their non-toxicity, easy fabrication, practical scalability, optical transparency, and low cost. However, because of the inherent hydrophobicity of PDMS-based material, biological samples easily and strongly interact with PDMS surfaces in biological environments, which prevents the immediate use of PDMS-based microfluidics without any surface processing. To date, various surface modification methods and different materials have been utilized to improve the repelling properties of the PDMS surface and to introduce new functional groups. Based on the recent advances in this field, we outline the main strategies utilized in PDMS surface modification in this review. We also present several applications of modified PDMS surfaces in biological analysis, such as biomolecule separation, immunoassay, cell culture, and DNA hybridization.

【 授权许可】

CC BY