Proton pump inhibitors: recent developments in analytical methodologies

Reviews in analytical chemistry

article

Mehul M. Patel¹  Satish D. Bhuva³  Miketa M. Patel⁴ 

[1] Department of Pharmaceutical Chemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology;Petlad;Veeda Clinical Research;Zydus Cadila Healthcare Ltd

关键词: analytical methods;    chromatography;    proton pump inhibitors;    spectroscopy;   

DOI  :  10.1515/revac-2014-0019

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

An extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals have been conducted, and the instrumental analytical methods that were developed and used for the determination of proton pump inhibitors in bulk drugs, formulations, and biological fluids have been reviewed. This review covers the time period from 1990 to 2011 during which 80 analytical methods, including all types of spectrophotometric and chromatographic techniques were reported. High-performance liquid chromatography (HPLC) with ultra violet (UV) detection was found to be the technique of choice for many workers, and more than 50 methods were based on liquid chromatography (LC) and ultra violet (UV). A critical analysis of the reported data was carried out and the present state of the art of the analytical techniques for the determination of omeprazole, esomeprazole, pantoprazole, rabeprazole, dexrabeprazole, tenatoprazole, lansoprazole, and dexlansoprazole is discussed.

【 授权许可】

CC BY