Biological nanoscale fluorescent probes: From structure and performance to bioimaging

Reviews in analytical chemistry

article

Jiafeng Wan¹  Xiaoyuan Zhang¹  Kai Zhang²  Zhiqiang Su¹ 

[1] State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology;Dental Medical Center, China-Japan Friendship Hospital

关键词: nano fluorescent probe materials;    semiconductor quantum dots;    metal nanoclusters;    carbon dots;    bioimaging;   

DOI  :  10.1515/revac-2020-0119

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

【 授权许可】

CC BY