Application of nanoparticles to reverse multi-drug resistance in cancer

Nanotechnology Reviews

article

Jie Yang¹  Haijun Zhang¹  Baoan Chen¹ 

[1] Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University

关键词: cancer;    multi-drug resistance (MDR);    nanoparticles (NPs);   

DOI  :  10.1515/ntrev-2016-0023

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Multi-drug resistance (MDR) poses a large obstacle to various human malignancies. For a long period, combination of multiple therapeutic agents has been the conventional method used to reverse MDR in cancer. However, it is still not an effective method as rather than cancer its serious side effects causes patient’s death. Nanoparticles (NPs) are emerging as a class of therapeutics for cancer, including overcoming MDR. In the present review, we focus on the application of NPs to reverse MDR in cancer. Several kinds of NPs developed for the reversal of MDR are summarized. In addition, investigations in vitro and in vivo are also shown to highlight the advancement in the application of NPs to reverse MDR.

【 授权许可】

CC BY