Noble metal nanoparticles in biosensors: recent studies and applications

Nanotechnology Reviews

article

Hedieh Malekzad¹  Parham Sahandi Zangabad²  Hamed Mirshekari²  Mahdi Karimi⁵  Michael R. Hamblin⁶ 

[1] Faculty of Chemistry, Kharazmi University;Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences;Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS);Department of Materials Science and Engineering, Sharif University of Technology;Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences;Wellman Center for Photomedicine, Massachusetts General Hospital;Department of Dermatology, Harvard Medical School;Division of Health Sciences and Technology

关键词: biomolecule detection;    colorometric;    electrochemical;    metal nanostructures;    nanobiosensor;    optical;    piezoelectric;   

DOI  :  10.1515/ntrev-2016-0014

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers and receptor immobilization, good ability for reaction catalysis and electron transfer, and good biocompatibility. MNPs can be used alone and in combination with other classes of nanostructures. MNP-based sensors can lead to significant signal amplification, higher sensitivity, and great improvements in the detection and quantification of biomolecules and different ions. Some recent examples of biomolecular sensors using MNPs are given, and the effects of structure, shape, and other physical properties of noble MNPs and nanohybrids in biosensor performance are discussed.

【 授权许可】

CC BY