Hydrogel based 3D carriers in the application of stem cell therapy by direct injection

Nanotechnology Reviews

article

Chengxin Luan¹  Ping Liu¹  Runzhe Chen¹  Baoan Chen² 

[1] Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, School of Medicine, Southeast University;Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University

关键词: 3D microcarriers;    direct injection;    hydrogel;    stem cell therapy;   

DOI  :  10.1515/ntrev-2017-0115

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Compared with systematic administration such as peripheral intravenous infusion, stem cell therapy by direct injection is theoretically more effective, but some technical barriers such as low stem cell retention rate and low engraftment rate still need to be overcome before its application in humans. Stem cell therapy supported by hydrogel carriers has been increasingly studied in recent years. These hydrogels with properties similar to natural tissues are able to fabricate various forms of carriers, which include in situ forming hydrogels, ex situ forming hydrogels, surface immobilization carriers, microencapsules, and microgels. Some of them are 3D carriers and promise to overcome the technical barriers of stem cell therapy by direct injection. They have different characteristics, application, and prospect in the application of stem cell therapy by direct injection, which is summarized by this review.

【 授权许可】

CC BY