Stimulus-responsive liposomes as smart nanoplatforms for drug delivery applications

Nanotechnology Reviews

article

Parham Sahandi Zangabad¹  Mahdi Karimi²  Michael R. Hamblin⁸  Soroush Mirkiani⁴  Shayan Shahsavari⁴  Behrad Masoudi⁴  Maryam Masroor⁴  Hamid Hamed⁴  Zahra Jafari⁴  Yasamin Davatgaran Taghipour⁴  Hura Hashemi⁴ 

[1] Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS);Cellular and Molecular Research Center, Iran University of Medical Sciences;Bio-Nano Interfaces: Convergence of Sciences (BNICS), Universal Scientific Education and Research Network (USERN);Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences;Nanomedicine Research Association (NRA), Universal Scientific Education and Research Network (USERN);Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences;Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences;Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School;Department of Dermatology, Harvard Medical School;Harvard-MIT Division of Health Sciences and Technology;Bioceramics and Implants Laboratory, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran;Nanoclub Elites Association, Iran Nanotechnology Initiative Council;Mataab Company, Biotechnology Incubator, Production and Research Complex, Pasteur Institute of Iran;School of Chemistry, College of Science, University of Tehran;School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran;Petroleum and Chemical Engineering Department, Sharif University of Technology;Department of Food Science and Technology, College of Agriculture and Food Science, Ayatollah Amoli Branch, Islamic Azad University;Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences;Faculty of Pharmacy, Tehran University of Medical Sciences

关键词: drug delivery;    external/internal stimuli;    liposomes;    nanocarriers;    smart stimulus responsive;   

DOI  :  10.1515/ntrev-2017-0154

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Liposomes are known to be promising nanoparticles (NPs) for drug delivery applications. Among the different types of self-assembled NPs, liposomes stand out for their non-toxic nature and their possession of dual hydrophilic-hydrophobic domains. The advantages of liposomes include the ability to solubilize hydrophobic drugs, the ability to incorporate different hydrophilic and lipophilic drugs at the same time, lessening the exposure of host organs to potentially toxic drugs and allowing modification of the surface by a variety of different chemical groups. This modification of the surface, or of the individual constituents, may be used to achieve two important goals. First, ligands for active targeting can be attached that are recognized by cognate receptors overexpressed on the target cells of tissues. Second, modification can be used to impart a stimulus-responsive or “smart” character to the liposomes, whereby the cargo is released on demand only when certain internal stimuli (pH, reducing agents, specific enzymes) or external stimuli [light, magnetic field, or ultrasound (US)] are present. Here, we review the field of smart liposomes for drug delivery applications.

【 授权许可】

CC BY