Novel Lead-free biocompatible piezoelectric Hydroxyapatite (HA) – BCZT (Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O 3 ) nanocrystal composites for bone regeneration

Nanotechnology Reviews

article

Chelli Sai Manohar¹  B Siva Kumar¹  Sai Pavan Prashanth Sadhu¹  Sai Krishna Srimadh²  V Sai Muthukumar¹  S. Venketesh²  K. B. R. Varma¹ 

[1] Sri Sathya Sai Institute Of Higher Learning, Prasanthinilayam Campus Puttaparthi;Deparment Of Bio-Sciences, Sri Sathya Sai Institute Of Higher Learning, Prasanthinilayam Campus Puttaparthi

关键词: Hydroxyapatite;    BCZT;    piezoelectricity;    bone regeneration;    biocompatibility;   

DOI  :  10.1515/ntrev-2019-0006

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

BCZT (Ba 0 . 85 Ca 0 . 15 Zr 0 .1Ti 0.9 O 3 ) is a recent class of lead-free ferroelectric material associated with high piezoelectric coefficient, making it suitable to inspire hydroxyapatite (HA)-BCZT ceramics for bone materials. Nano-crystalline hydroxyapatite (HA) synthesized using the hydrothermal route was characterized via FT-IR, Raman spectroscopy, X-ray powder diffraction (XRD), and Scanning Electron Microscopy (SEM). We also rationalized its formation as a function of operating conditions such as dwell time and temperature in this route. The nano-crystalline BCZT powder was synthesized via a sol-gel technique and its structural and morphological characterization were carried out using Raman Spectroscopy, XRD and Transmission Electron Microscopy (TEM). These investigations facilitated the optimization of HA-BCZT compositions and their electrical poling conditions to achieve enhanced piezoelectric effect. The composites (HA-BCZT) sintered at 1350 ∘ C exhibited promising piezoelectric properties. We report the enhanced piezoelectric coefficient (d 33 ) of 7±1 pC/N for 50% HA-BCZT which is significant as compared to that reported in the literature for ~98% BT (barium titanate) -HA composites. We highlight the role of Simulated Body Fluid (SBF) on the intriguing phase-change of Tricalcium Phosphate (TCP) obtained at this sintering temperature, to hydroxyapatite for its essential contribution to promote bone growth. We theoretically support the confirmed in vitro biocompatibility of these composites.

【 授权许可】

CC BY