Optically responsive delivery platforms: from the design considerations to biomedical applications

Nanophotonics

article

Irina Koryakina¹  Daria S. Kuznetsova²  Dmitry A. Zuev¹  Valentin A. Milichko¹  Alexander S. Timin³  Mikhail V. Zyuzin¹ 

[1] Faculty of Physics and Engineering, ITMO University;Privolzhsky Research Medical University, Institute of Experimental Oncology and Biomedical Technologies;Research School of Chemical and Biomedical Engineering, National Research Tomsk Polytechnic University

关键词: light-responsive drug carriers;    release mechanisms;    plasmonic nanoparticles;    resonant dielectric nanoparticles;    biomedical applications;    tumour treatment;   

DOI  :  10.1515/nanoph-2019-0423

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

【 授权许可】

CC BY