Efficient synthesis of 2,4-disubstituted thiazoles and 2-substituted 4-thiazolidinones under solvent free conditions

Heterocyclic communications

article

Deepika Gautam¹  Poonam Gautam¹  Ram P. Chaudhary¹ 

[1] Department of Chemistry, Sant Longowal Institute of Engineering and Technology

关键词: grinding;    ionic liquid;    thiazoles;    thiosemicarbazones;    4-thiazolidinones;   

DOI  :  10.1515/hc.2011.027

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Condensation of thiosemicarbazones 2 derived from 1-tetralones ( 1 ) with chloroacetic acid in presence of N -methylpyridinium tosylate (an ionic liquid) yields 2-substituted-4-thiazolidinones 3 . The reaction of 2 with α-halo carbonyl compounds at room temperature under grinding conditions yields 2,4-disubstituted thiazoles 4 in excellent yields. The structures of compounds 2–4 have been esta­b­lished on the basis of elemental analysis, IR, NMR and mass spectral data.

【 授权许可】

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