Selective deprotection of tethered glycoderivatives with unsaturated spacer

Heterocyclic communications

article

Mihai-Cosmin Pascariu¹  Lucian Mircea Rusnac¹ 

[1] “Politehnica” University of Timişoara, Faculty of Industrial Chemistry and Environmental Engineering

关键词: acetonide;    deprotection;    iodine;    isopropylidene;    monosaccharide;    tether;   

DOI  :  10.1515/hc.2011.022

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A double regioselective deprotection of symmetrical tethered isopropylidenated monosaccharides has been elaborated. This mild and simple methodology involving iodine and acetonitrile, allows breaking of dioxolane and dioxane moieties and affords new chiral structures in good yields. Spectroscopic characterization of these molecules includes FTIR, ESI-MS, 1 H and 13 C NMR, and also 2D-COSY, HMQC and HMBC measurements.

【 授权许可】

CC BY|CC BY-NC-ND