Heterocyclic communications | |
Canataxpyran A, a novel 3,8-secotaxane with a 13,17-ether bridge from needles of Taxus canadensis | |
article | |
Yong Li1  Man-Li Zhang3  Yu-Fang Wang3  Mei Dong1  Françoise Sauriol4  Qing-Wen Shi1  Hiromasa Kiyota5  Yu-Cheng Gu6  Bin Cong1  | |
[1] Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University;Department of Thoracic, Fourth Hospital of Hebei Medical University;School of Pharmaceutical Sciences, Hebei Medical University;Department of Chemistry, Queen’s University;Graduate School of Agricultural Science, Tohoku University;Jealott’s Hill International Research Centre | |
关键词: isolation; needle; 3; 8-secotaxane; Taxaceae; Taxus canadensis; | |
DOI : 10.1515/hc-2012-0035 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
A novel 6/12-membered bicyclic taxane with a 13,17-ether bridge, named canataxpyran A, was isolated from the needles of Taxus canadensis . The structures were characterized as 7β,9,10β,20-tetracetoxy-13β,17-epoxy-3,8-secotaxa-3 E ,8 E ,11-triene-2α,5α-diol (designated as canataxpyran A, 1 ). This bicyclic taxane gradually decomposed in CDCl 3 to give the corresponding enones, 10β,20-diacetoxy-13β,17-epoxy-4α,5α-dihydroxy-3,8-secotaxa-2 E ,7 E ,11-trien-9-one (canataxpyran B, 2 ) and 5α,10β,20-triacetoxy-13β,17-epoxy-4α-hydroxy- 3,8-secotaxa-2 E ,7 E ,11-trien-9-one (canataxpyran C, 3 ). Compound 1 is the first example of a natural 3,8-secotaxane with 13,17-oxygen bridge.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
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