Fast and efficient microwave synthetic methods for some new 2(1H)-pyridone arabinosides

Heterocyclic communications

article

Ibrahim M. Abdou¹  Nora M. Rateb²  Hany A. Eldeab¹ 

[1] Faculty of Science, Department of Chemistry, UAE University, United Arab Emirates;Faculty of Science, Department of Chemistry, Cairo University

关键词: microwave;    2-pyridone arabinosides;    synthesis;   

DOI  :  10.1515/hc-2012-0091

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Two series of novel 3-cyano-2-(2′′,3′′,4′′-tri- O -acetyl- β - D -arabinopyranosyloxy)pyridones 5a–h and 9a,b were synthesized. Microwave irradiation has been used to obtain these products in high yield under milder conditions by the reaction of 2(1 H )-pyridone or its salt with an activated arabinose. The silyl method was used to obtain the same nuclesides 5a–h and 9a,b . Triethylamine was used to remove the acetyl protecting groups from the sugar moiety and to produce the free nucleosides 6a–h and 10a,b in 85–91% yield.

【 授权许可】

CC BY|CC BY-NC-ND