Synthesis of new tetracyclic paullone derivatives as potential CDK inhibitors

Heterocyclic communications

article

Efthimia G. Koutsandrea¹  Manolis A. Fousteris¹  Sotiris S. Nikolaropoulos¹ 

[1] Laboratory of Medicinal Chemistry, Department of Pharmacy, University of Patras

关键词: azepinone;    Heck coupling;    kinase tetracyclic core;    paullones;   

DOI  :  10.1515/hc-2012-0121

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Synthetic efforts towards new tetracyclic heterocycles bearing the pyrrolo[2′,3′:5,6]azepino[4,3- b ]indol-4(11 H )-one core are described. Synthesized tetracyclic compounds are the first analogs, structurally related to protein kinase inhibitors paullones which incorporate an azepinone, an indole and a pyrrole ring. The synthetic approach involves palladium mediated intramolecular Heck coupling as a key step.

【 授权许可】

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