Synthesis of new heterocyclic compounds containing benzimidazole moiety as inhibitors of breast cancer cell growth

Heterocyclic communications

article

Atif Tantawy¹  Alaa-eldin Barghash¹  Sahar Badr¹  Rania Gomaa¹ 

[1] Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, University of Mansoura

关键词: antitumor;    benzimidazoles;    benzoxazines;    quinolines;    quinoxalines;    1;    2;    4-triazines;    synthesis;   

DOI  :  10.1515/hc-2013-0013

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A series of new benzimidazole derivatives, namely 2-acylbenzimidazoles 2–9 , a dihydroquinoxaline 10 , a benzoxazine 11 , quinolines 13–15 and fused 1,2,4-triazines 17–24 were synthesized. Structure elucidation of the compounds was conducted using IR, 1 H NMR, 13 C NMR, mass spectral data and elemental analysis. These products were evaluated for in vitro antitumor activity against MCF7 cell line (human breast cancer). Compounds 13–15 and 24 manifested significant antitumor activity.

【 授权许可】

CC BY|CC BY-NC-ND