One-pot synthesis and crystal structure of an unusual amidine derived from heterocyclic ketene aminal derivative

Heterocyclic communications

article

Penghui Yang¹  Wenzhen Wang¹  Yanshan Duan¹  Chengtun Qu¹  Qunzheng Zhang¹ 

[1] College of Chemistry and Chemical Engineering, Xi’an Shiyou University

关键词: amidine;    catalyst;    crystal structure;    heterocyclic ketene aminal (HKA);    ketene aminals;    synthesis;   

DOI  :  10.1515/hc-2012-0161

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

One-pot reaction of Meldrum’s acid ( 1 ) and heterocyclic ketene aminal (HKA, 2 ) in acetone affords an unusual amidine HKA derivative 4 . The reaction catalysts were optimized and it was found that l -proline is the best catalyst for the one-pot reaction. The mechanism is discussed. The structure of compound 4 was determined by single crystal X-ray analysis.

【 授权许可】

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