Design, synthesis, antibacterial, and antifungal studies of novel 3-substituted coumarinyl-triazine derivatives

Heterocyclic communications

article

Rahul P. Modh¹  Amit C. Patel²  Kishor H. Chikhalia¹ 

[1] Department of Chemistry, School of Sciences, Gujarat University;Department of Chemistry, Veer Narmad South Gujarat University

关键词: antibacterial activity;    antifungal activity;    coumarins;    oxadiazoles;    triazines;   

DOI  :  10.1515/hc-2013-0104

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A series of novel 3-substituted coumarinyl-triazine derivatives were designed and synthesized from 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water. All synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, MS, and elemental analysis. Further, in vitro screening was carried out against four bacterial strains ( Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Salmonella typhi ) and two fungal strains ( Aspergillus niger and Aspergillus clavatus ).

【 授权许可】

CC BY|CC BY-NC-ND