Methods for the synthesis of xanthine-derived polycyclic fused systems

Heterocyclic communications

article

Ewa Szymańska¹  Jakub Mazurkiewicz¹  Katarzyna Kieć-Kononowicz¹ 

[1] Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College

关键词: adenosine receptor;    heterocyclic fused systems;    phosphodiesterase;    purine-2;    6-dione;    xanthine;   

DOI  :  10.1515/hc-2013-0082

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Xanthines are a widely known group of alkaloids, commonly used as bronchodilators and psycho and cardiac stimulants. Most of their actions are principally connected with either antagonism of adenosine receptors or phosphodiesterase inhibition; nevertheless, other profiles of their biological activity – antiviral, antitumor or anticancer – are also known. Here, we present a review of the main synthetic methods to obtain xanthine-derived heterocyclic fused systems. The five-, six- or seven-membered heterocyclic ring is attached to the purine-2,6-dione core with one or two bridgehead (ring junction) nitrogen atoms. The biological activity profile of the individual heterocyclic systems is mentioned.

【 授权许可】

CC BY|CC BY-NC-ND