Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity

Heterocyclic communications

article

Agnieszka A. Kaczor¹  Kalevi Pihlaja³  Jari Sinkkonen³  Kirsti Wiinamäki³  Christiane Kronbach⁴  Klaus Unverferth⁴  Tomasz Wróbel¹  Tomasz Stachal¹  Dariusz Matosiuk¹ 

[1] Faculty of Pharmacy with Division of Medical Analytics, Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Medical University of Lublin;School of Pharmacy, University of Eastern Finland;Department of Chemistry, University of Turku;Biotie Therapie GmbH

关键词: carbazole derivatives;    GluK2 receptor;    indole derivatives;    kainate receptors;   

DOI  :  10.1515/hc-2014-0006

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Indole and carbazole derivatives were designed as non-competitive antagonists of the GluK2 receptor. The synthesized compounds were found to interact with the transduction domain of the receptor. The binding pocket is situated within one receptor subunit.

【 授权许可】

CC BY|CC BY-NC-ND