Solvent-free multicomponent assembling of aldehydes, N,N′-dialkyl barbiturates and malononitrile: fast and efficient approach to pyrano[2,3-d]pyrimidines

Heterocyclic communications

article

Michail N. Elinson¹  Fedor V. Ryzhkov¹  Valentina M. Merkulova¹  Alexey I. Ilovaisky¹  Gennady I. Nikishin¹ 

[1] N. D. Zelinsky Institute of Organic Chemistry

关键词: aldehydes;    multicomponent reaction;    N;    N′-dialkyl barbiturates;    pyrano[2;    3-d]pyrimidines;    solvent-free;   

DOI  :  10.1515/hc-2014-0114

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Potassium fluoride-catalyzed solvent-free multicomponent reaction of aldehydes, N , N ′-dialkyl barbiturates and malononitrile results in the fast (15 min) and efficient (yields 89–95%) formation of substituted pyrano[2,3- d ]pyrimidines. The improved synthetic methodology for this class of bioactive compounds is important from the viewpoint of diversity-oriented large-scale processes and represents an environmentally benign solvent-free synthetic concept for multicomponent reactions strategy.

【 授权许可】

CC BY|CC BY-NC-ND