Synthesis of new derivatives of 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines

Heterocyclic communications

article

Zahra Arghiani¹  Seyed Mohammad Seyedi¹  Mehdi Bakavoli¹  Mohsen Nikpour² 

[1] Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad;Department of Chemistry, Islamic Azad University, Ahvaz Branch

关键词: 4-bromo-3;    6-dichloropyridazine;    4-bromo-1;    2- dihydropyridazine-3;    6-dione;    3-bromomaleic anhydride;    10H-benzo[b]pyridazino[3;    4-e][1;    4]thiazines;    heterocyclization;    15-lipoxygenase inhibitor;   

DOI  :  10.1515/hc-2015-0055

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

New 10 H -benzo[ b ]pyridazino[3,4- e ][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.

【 授权许可】

CC BY|CC BY-NC-ND