Formation of 1-methyl[1,2,4]triazolo[4,3-a] quinazolin-5(4H)-ones by reaction of 2-hydrazinoquinazolin-4(3H)-ones with acetylacetone

Heterocyclic communications

article

Svitlana Yuriyivna Danylchenko¹  Oleksandr Grygorovych Drushlyak¹  Svitlana Sergiyivna Kovalenko¹  Sergiy Mykolayovych Kovalenko² 

[1] The National University of Pharmacy;Kharkiv National University

关键词: acetylacetone;    amide formation;    2-hydrazinoquinazolin-4(3H)-one;    pyrazole;    [1;    2;    4]triazolo[4;    3-a]quinazolin-5(4H)-one;   

DOI  :  10.1515/hc-2015-0104

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Reaction of 2-hydrazinoquinazolin-4(3 H )-ones with acetylacetone results in the formation of 1-methyl[1,2,4]triazolo[4,3- a ]quinazolin-5(4 H )-ones instead of 2-(3,5-dimethyl-1 H -pyrazol-1-yl)quinazolin-4(3 H )-ones. Under similar conditions, the 7-hydrazinocarbonyl group in quinazolin-4(3 H )-one moiety is transformed into a pyrazole derivative, which can be replaced by amine with the amide formation.

【 授权许可】

CC BY|CC BY-NC-ND