An efficient, one-pot three-component synthesis of 4H-thiazolo[3,2-a][1,3,5]triazin-6-one derivatives

Heterocyclic communications

article

Mustafa T. Ubeid¹  Hamdy K. Thabet¹  Said A. El-Feky³ 

[1] Faculty of Arts and Science, Department of Chemistry, Northern Border University;Faculty of Science, Department of Chemistry, Al-Azhar University;Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Northern Border University

关键词: multicomponent reaction;    one-pot reaction;    thiazolo[3;    2-a][1;    3;    5]triazin-6-ones;   

DOI  :  10.1515/hc-2015-0135

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A simple and efficient protocol was established to synthesize thiazolo[3,2- a ][1,3,5]triazin-6-ones via three-component one-pot condensation reaction of readily available thioglycolic acid or ethyl thioglycolate, aldehydes or ketones and dicyandiamide in the presence of ammonium acetate. All of the newly synthesized compounds were characterized by spectroscopic analyses.

【 授权许可】

CC BY|CC BY-NC-ND