Synthesis of 6-alkylsulfanyl-1,4-dihydropyridines as potential multidrug resistance modulators

Heterocyclic communications

article

Aivars Krauze¹  Laura Krasnova¹  Signe Grinberga¹  Elina Sokolova¹  Ilona Domracheva¹  Irina Shestakova¹  Gunars Duburs¹ 

[1] Latvian Institute of Organic Synthesis

关键词: dihydropyridines;    efflux pump inhibition;    multidrug resistance (MDR);    multidrug resistance protein-1 (MRP1);    one-pot reaction;    P-glycoprotein (P-gp);   

DOI  :  10.1515/hc-2016-0034

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

6-Alkylsulfanyl-1,4-dihydropyridines 5 bearing methoxyphenyl groups at various positions have been prepared by three different approaches. Multidrug resistance modulating (P-glycoprotein and multidrug resistance protein-1 inhibition) activity of 1,4-dihydropyridine derivatives 5 is comparable to that of verapamil.

【 授权许可】

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