期刊论文详细信息
Heterocyclic communications | |
Design, synthesis and cytotoxicity evaluation of novel (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones as anticancer agents | |
article | |
Raquib Alam1  Md. Aftab Alam2  Amulya K. Panda3  Rahis Uddin1  | |
[1] Department of Chemistry, Jamia Millia Islamia (A Central University);Department of pharmacy, School of Medical and Allied Science, Galgotias University;Product Development Cell, National Institute of Immunology | |
关键词: chalcones; Claisen-Schmidt condensation; cytotoxic activity; pyrazoles; | |
DOI : 10.1515/hc-2016-0042 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
( E )-3-(3-Aryl-1-phenyl-1 H -pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones 4a–i have been synthesized and evaluated for their in vitro cytotoxicity against a panel of three human cancer cell lines Caco-2, MIA PaCa-2, MCF-7 and a normal NIH-3T3 cell line. Compound 4g is cytotoxic with the IC 50 value of 15.32±0.62 μ m against the Caco-2 cell line.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107200002382ZK.pdf | 133KB | download |