Design, synthesis and cytotoxicity evaluation of novel (E)-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones as anticancer agents

Heterocyclic communications

article

Raquib Alam¹  Md. Aftab Alam²  Amulya K. Panda³  Rahis Uddin¹ 

[1] Department of Chemistry, Jamia Millia Islamia (A Central University);Department of pharmacy, School of Medical and Allied Science, Galgotias University;Product Development Cell, National Institute of Immunology

关键词: chalcones;    Claisen-Schmidt condensation;    cytotoxic activity;    pyrazoles;   

DOI  :  10.1515/hc-2016-0042

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

( E )-3-(3-Aryl-1-phenyl-1 H -pyrazol-4-yl)-1-(pyridin-3-yl)prop-2-en-1-ones 4a–i have been synthesized and evaluated for their in vitro cytotoxicity against a panel of three human cancer cell lines Caco-2, MIA PaCa-2, MCF-7 and a normal NIH-3T3 cell line. Compound 4g is cytotoxic with the IC 50 value of 15.32±0.62 μ m against the Caco-2 cell line.

【 授权许可】

CC BY|CC BY-NC-ND