期刊论文详细信息
Heterocyclic communications | |
Br2- or HBr-catalyzed synthesis of asymmetric 3,3-di(indolyl)indolin-2-ones | |
article | |
Yanni Li1  Deqiang Liang1  Xiangguang Li1  Wenzhong Huang1  Lin Yuan1  Baoling Wang1  Ping Cheng3  | |
[1] Department of Chemistry, Kunming University;Key Laboratory of Yunnan Provincial Higher Education Institutions for Organic Optoelectronic Materials and Devices, Kunming University;School of Environmental and Chemical Engineering, Shanghai University | |
关键词: alcohols; alkylation; C–C coupling; halogens; homogeneous catalysis; | |
DOI : 10.1515/hc-2016-0071 | |
学科分类:内科医学 | |
来源: De Gruyter | |
【 摘 要 】
Under the catalysis of 1 mol% of Br 2 or HBr at room temperature, indoles undergo a rapid reaction with 3-hydroxy-3-(indol-3-yl)indolin-2-ones to give asymmetric 3,3-di(indol-3-yl)indolin-2-ones with high efficiency and wide substrate scope. This is a rare example of Br 2 acting as a Lewis acid catalyst. Theoretical calculations suggest that both the catalytic activity of the catalysts and the stability of reaction intermediates are responsible for the high efficiency of this reaction.
【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107200002356ZK.pdf | 230KB | download |