Br2- or HBr-catalyzed synthesis of asymmetric 3,3-di(indolyl)indolin-2-ones

Heterocyclic communications

article

Yanni Li¹  Deqiang Liang¹  Xiangguang Li¹  Wenzhong Huang¹  Lin Yuan¹  Baoling Wang¹  Ping Cheng³ 

[1] Department of Chemistry, Kunming University;Key Laboratory of Yunnan Provincial Higher Education Institutions for Organic Optoelectronic Materials and Devices, Kunming University;School of Environmental and Chemical Engineering, Shanghai University

关键词: alcohols;    alkylation;    C–C coupling;    halogens;    homogeneous catalysis;   

DOI  :  10.1515/hc-2016-0071

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Under the catalysis of 1 mol% of Br 2 or HBr at room temperature, indoles undergo a rapid reaction with 3-hydroxy-3-(indol-3-yl)indolin-2-ones to give asymmetric 3,3-di(indol-3-yl)indolin-2-ones with high efficiency and wide substrate scope. This is a rare example of Br 2 acting as a Lewis acid catalyst. Theoretical calculations suggest that both the catalytic activity of the catalysts and the stability of reaction intermediates are responsible for the high efficiency of this reaction.

【 授权许可】

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