Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Heterocyclic communications

article

Phillip D. Wilkerson¹  Andrew C. Bean¹  Chad E. Stephens¹ 

[1] Department of Chemistry and Physics, Augusta University

关键词: 1;    4-benzothiazine;    acyl transfer;    antiviral sulfone;    cyclodehydration;    iron reduction;   

DOI  :  10.1515/hc-2017-0028

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

2-Cyano-substituted 1,4-benzothiazine 1,1-dioxides, required for antiviral studies, were prepared by a reductive cyclodehydration of an ortho -nitro sulfone precursor containing a pendant aryl ketone group. The ring-forming reaction also furnishes a non-cyclized benzamide as a major byproduct via an unexpected acyl transfer reaction.

【 授权许可】

CC BY|CC BY-NC-ND