Ultrasound mediated synthesis of dihydropyrano[3,2-d][1,3]dioxin-7-carbonitrile derivatives in H2O/EtOH medium

Heterocyclic communications

article

Mohammad M. Mojtahedi¹  Masoomeh Mehraban¹  Kiana Darvishi¹  M. Saeed Abaee¹ 

[1] Organic Chemistry Department, Chemistry and Chemical Engineering Research Center of Iran

关键词: aqueous;    1;    3-dioxane-5-one;    multicomponent reaction;    one-pot synthesis;    ultrasonication;   

DOI  :  10.1515/hc-2017-0014

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A one-pot cyclocondensation of 1,3-dioxane-5-one ( 1 ) with malononitrile and aromatic aldehydes in aqueous sodium hydroxide under ultrasonic irradiation furnishes a series of pyrano[3,2- d ][1,3]dioxin derivatives 3 . Reactions are completed after a few minutes and the precipitated products are purified by simple crystallization from ethanol. The reaction with ethyl cyanoacetate instead of malononitrile gives the respective analogous products in high yields.

【 授权许可】

CC BY|CC BY-NC-ND