Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives

Heterocyclic communications

article

Danling Huang¹  Xiaoguang Wang¹  Aiping Liu¹  Weidong Liu¹  Xingping Liu¹  Yeguo Ren¹  Xi Zheng¹  Hui Pei¹  Jun Xiang¹  Mingzhi Huang¹ 

[1] National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry;College of Chemistry and Chemical Engineering, Hunan Normal University;Hunan Province Key Laboratory for Agrochemicals

关键词: insecticidal activity;    oxazole;    pyrazole;    structure-activity relationship;    thiazole;   

DOI  :  10.1515/hc-2017-0110

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Fourteen 1 H -pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1 H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30–50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays’ results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.

【 授权许可】

CC BY|CC BY-NC-ND