Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 cells

Heterocyclic communications

article

Li Fei Nie¹  Guozheng Huang¹  Khurshed Bozorov¹  Jiangyu Zhao¹  Chao Niu¹  Shamansur S. Sagdullaev²  Haji A. Aisa¹ 

[1] Key Laboratory of Plant Resources and Chemistry in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences;Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan

关键词: melanin synthesis;    murine B16 cells;    thieno[2;    3-d]pyrimidin-4(3H)-one;    vitiligo;   

DOI  :  10.1515/hc-2017-0256

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

A diversity-oriented synthesis of amide-containing thieno[2,3- d ]pyrimidin-4(3 H )-ones is reported. All compounds were tested for their influence on melanin synthesis in murine B16 cells. The azepine fragment in thieno[2,3- d ]pyrimidin-4(3 H )-one skeleton significantly increases the melanin content.

【 授权许可】

CC BY|CC BY-NC-ND