Microwave-assisted synthesis of quinazolin-4(3H)-ones catalyzed by SbCl3

Heterocyclic communications

article

Huaiyuan Kang¹  Weili Wang¹  Qinqiang Sun¹  Shuya Yang¹  Juan Jin¹  Xuewen Zhang¹  Xiaoliang Ren²  Jiming Zhang²  Jianhua Zhou² 

[1] School of Chemistry and Material Science, Ludong University;School of Chemistry and Pharmaceutical Engineering, Qilu University of Technology

关键词: microwave irradiation;    quinazolin-4(3H)-ones;    SbCl3;    solvent-free;   

DOI  :  10.1515/hc-2018-0115

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Antimony(III) trichloride (SbCl 3 ) is an effective catalyst (1 mol%) for the condensation of anthranilic amide with various aldehydes or ketones to quinazolin-4(3 H )-one derivatives in good to excellent yields under microwave irradiation. The process is carried out within several minutes under solvent-free conditions. This general methodology has the advantages of simplicity, mild reaction conditions and high yields of products.

【 授权许可】

CC BY|CC BY-NC-ND