Coumarin sulfonamide derivatives: An emerging class of therapeutic agents

Heterocyclic communications

article

Ali Irfan¹  Laila Rubab¹  Mishbah Ur Rehman¹  Rukhsana Anjum¹  Sami Ullah¹  Mahwish Marjana¹  Saba Qadeer¹  Sadia Sana¹ 

[1]Department of Chemistry, The University of Lahore, Sargodha Campus

[2]Department of Chemistry, Lahore College for Women University

关键词: coumarin sulfonamide;    biological activities;    antimicrobial;    anti-cancer;    anti-inflammatory;    anti-oxidant;   

DOI  :  10.1515/hc-2020-0008

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Coumarin sulfonamide is a heterocyclic pharmacophore and an important structural motif which is a core and integral part of different therapeutic scaffolds and analogues. Coumarin sulfonamides are privileged and pivotal templates which have a broad spectrum of applications in the fields of medicine, pharmacology and pharmaceutics. Coumarin sulfonamide exhibited versatile and myriad biomedical activities such as anti-bacterial, antiviral, antifungal, anti-inflammatory and anti-cancer. This review article focuses on the structural features of coumarin sulfonamide derivatives in the treatment of different lethal diseases on the basis of structure-activity relationships (SAR). The plethora of research cited in this review article summarizes and discusses the various substitutions around the coumarin sulfonamide nucleus which have provided a wide spectrum of biological activities and therapeutic potential that has proved attractive to many researchers looking to exploit the coumarin sulfonamide skeleton for drug discovery and the development of novel therapeutic agents.

【 授权许可】

CC BY|CC BY-NC-ND