An improved and sustainable approach for the synthesis of α,β-dibromo ketones using ceric ammonium nitrate and ammonium bromide

Green Processing and Synthesis

article

Balaji B. Totawar¹  Pramod S. Kulkarni²  Zubaidha K. Pudukulathan¹ 

[1] School of Chemical Sciences, Swami Ramanand Teerth Marathwada University;Department of Chemistry

关键词: α;    β-unsaturated ketone;    ammonium bromide;    bromination;    CAN;    dibromo ketone;    grinding;    sustainable approach;   

DOI  :  10.1515/gps-2015-0097

来源: De Gruyter

【 摘 要 】

A simple and environmentally benign procedure for the bromination of substituted α,β-unsaturated ketones in good yield has been described using ammonium bromide as a brominating agent and ceric ammonium nitrate (CAN) as a single-electron oxidant to afford α,β-dibromoketones. The reaction involves C-Br bond formation by radical method generated by CAN. The reaction can be carried out by either at room temperature, stirring in solvent CH 3 CN or under aqueous moist condition with few drops of water by manual grinding in a mortar and pestle.

【 授权许可】

CC BY