Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions

Green Processing and Synthesis

article

Ramandeep Kaur¹  Bhupinder Kumar¹  Ashish Ranjan Dwivedi¹  Vinod Kumar¹ 

[1] Laboratory of Organic and Medicinal Chemistry, Centre for Pharmaceutical Sciences and Natural Products, Central University of Punjab

关键词: 1;    2;    4-triazole;    green chemistry;    ionic liquids;    microwave;    regioselective alkylation;   

DOI  :  10.1515/gps-2015-0138

来源: De Gruyter

【 摘 要 】

1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective protocol has been developed for the alkylation of 1,2,4- triazole using mild conditions. The 1-alkyl-1,2,4-triazole derivatives were synthesized under microwave conditions using potassium carbonate as a base and ionic liquid (hexylpyridinium bromide) as a solvent. The products were obtained in excellent yield, and the base-ionic liquid combination was recycled for a number of times.

【 授权许可】

CC BY