Study on characteristics, properties, and morphology of poly(lactic acid)/chitosan/hydroquinine green nanoparticles

Green Processing and Synthesis

article

Nguyen Thi Thu Trang¹  Tran Thi Mai¹  Nguyen Vu Giang¹  Tran Huu Trung¹  Do Van Cong¹  Nguyen Thuy Chinh¹  Trinh Hoang Trung¹  Tran Dai Lam²  Thai Hoang¹ 

[1] Institute for Tropical Technology;Graduate University of Science and Technology

关键词: antimalarial;    chitosan (CS);    drug release;    hydroquinine (Hq);    nanoparticles;    poly(lactic acid) (PLA);   

DOI  :  10.1515/gps-2018-0025

来源: De Gruyter

【 摘 要 】

Poly(lactic acid)/chitosan (PLA/CS) green nanoparticles containing hydroquinine (Hq) were prepared by emulsion method. The content of Hq was 10–50 wt% compared with the weight total of PLA and CS. The characteristics of these nanoparticles were analyzed by Fourier transform infrared (FTIR), differential scanning calorimetry, field emission scanning electron microscopy (FESEM), and particle size analysis. The wavenumbers of C=O, C=N, OH, and CH 3 groups in FTIR spectra of the PLA/CS/Hq (PCHq) nanoparticles shifted in comparision with neat PLA, CS, and Hq that proved the interaction between these components. The FESEM images and particle size analysis results showed that the basic particle size of PCHq nanoparticles ranged between 100 and 200 nm. The Hq released from PLA/CS nanoparticles in pH 2 and pH 7.4 solutions was determined by ultraviolet-visible method. The obtained results indicated that the linear regression coefficient of calibration equation of Hq in the above solutions approximates 1. The Hq release from the PCHq nanoparticles includes fast release for the eight first testing hours, and then, controlled slow release. The Hq released process was obeyed according to the Korsmeyer-Peppas kinetic model.

【 授权许可】

CC BY