Iodination of industrially important aromatic compounds using N-iodosuccinimide by grinding method

Green Processing and Synthesis

article

Vivek Sharma¹  Priyanka Srivastava²  Santosh Kumar Bhardwaj²  D.D. Agarwal² 

[1] Department of Chemistry, Baba Farid College;Department of Industrial Chemistry, Jiwaji University

关键词: aromatic;    catalysis;    iodoarenes;    regiospecific;   

DOI  :  10.1515/gps-2017-0072

来源: De Gruyter

【 摘 要 】

Iodination of various industrially and pharmaceutically important substituted aromatics has been achieved using N-iodosuccinimide (NIS) in solid state by grinding at room temperature. This method provides several advantages such as short reaction time (5–8 min), high yields (94–99%), and nonhazardous and simple work-up procedure. High gas chromatography (GC) purity (95–99.9%) suggests that the reaction is highly selective. Substrates which are sensitive to oxidation, viz aniline and phenols are iodinated smoothly in high yield.

【 授权许可】

CC BY