Complete Resolution of Wegener’s Granulomatosis Lung Granuloma After Aortic Root Replacement

AORTA

article

Sarah-Jayne Edmondson¹  Saina Attaran¹  Ulrich P. Rosendahl¹ 

[1] Royal Brompton Hospital NHS Foundation Trust, Department of Cardiothoracic Surgery

关键词: Aortic root;    Dissection;    Inflammation;    Wegener’s granulomatosis;   

DOI  :  10.12945/j.aorta.2015.15.009

来源: Thieme

【 摘 要 】

Wegner’s granulomatosis (WG) is an autoimmune systemic vasculitis that results in necrotizing granulomas. We report a WG patient with a lung granuloma and aortic root dilatation, who underwent aortic root replacement on cardiopulmonary bypass (CPB). Intraoperatively, the patient suffered an aortic dissection, which was repaired immediately under deep hypothermic circulatory arrest (DHCA). Follow-up imaging showed complete granuloma resolution, despite absence of immunosuppressive therapy. Immune stimulation following CPB is well described; here, the opposite was observed and DHCA effects are discussed.

【 授权许可】

Unknown