Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition

Frontiers in Medicine

Jwu-Lai Yeh¹  Bin-Nan Wu¹  Chee-Yin Chai²  Yi-Ching Liu³  Jong-Hau Hsu⁴  I-Chen Chen⁵  Zen-Kong Dai⁵  Jao-Yu Lin⁶ 

[1] College of Medicine, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Pathology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;College of Medicine, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan;

关键词: pulmonary arterial hypertension;    left pneumonectomy;    SU5416;    ACE2 activator;    diminazene aceturate;    ACE2-Ang (1-7)-Mas axis;   

DOI  :  10.3389/fmed.2021.619133

来源: Frontiers

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