Fetal Intraventricular Hemorrhage Due to Antiphospholipid Syndrome: A Case Report

Frontiers in Pediatrics

J. W. Bouwhuis¹  G. van Wezel-Meijler²  M. C. Bouw²  S. W. A. Nij Bijvank³ 

[1] Department of Internal Medicine, Isala Hospital, Zwolle, Netherlands;Department of Neonatology, Isala Women and Children's Hospital, Zwolle, Netherlands;Department of Obstetrics and Gynecology, Isala Women and Children's Hospital, Zwolle, Netherlands;

关键词: antiphospholipid syndrome;    obstetric antiphospholipid syndrome;    antiphospholipid antibodies;    prematurity;    lupus anticoagulant;    case report;    fetal intraventricular hemorrhage;   

DOI  :  10.3389/fped.2020.622597

来源: Frontiers

【 摘 要 】

Obstetric Antiphospholipid Syndrome (OAPS) is an autoimmune disease characterized by certain pregnancy complications in association with persistent antiphospholipid antibodies. These antibodies are generally known for their prothrombotic characteristics and may affect mother and fetus during the entire pregnancy. The clinical criteria for OAPS, including recurrent fetal loss, intra-uterine growth restriction and premature birth due to severe preeclampsia, all suggest uteroplacental vascular insufficiency. Although rare, thrombotic complications have been described in neonates born to mothers with OAPS, mainly ischemic stroke. We report on the first case of extensive fetal intraventricular hemorrhage related to OAPS. We share our diagnostic search and analysis for this unusual antenatal event, including cranial ultrasound findings and postmortem MRI images. We will also present a short review of the etiology and prognosis of antenatal intraventricular hemorrhage. We suggest that women with severe or early preeclampsia and/or a history of pregnancy loss should be evaluated for OAPS and carefully monitored throughout pregnancy. Further, we advise to test mothers for OAPS in the case of idiopathic fetal hemorrhage.

【 授权许可】

CC BY