Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis

Frontiers in Medicine

Chia-Yu Yang¹  Hsuan Liu²  Hwei-Jen Lee³  Shih-Ming Huang³  Jhao-Jhuang Ding⁴  Jing-Long Huang⁵  Shih-Hua Lin⁶  Min-Hua Tseng⁷  Wen-Lang Fan⁸ 

[1] College of Medicine, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan;Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan;Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan;Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan;College of Medicine, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan;Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan;Division of Colon and Rectal Surgery, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan;Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;Division of Asthma, Allergy, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan;Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;Division of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan;Department of Pediatrics, Xiamen Chang Gung Hospital, Ximen, China;Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan;

关键词: lupus nephritis;    thrombotic microangiopathy;    genetic background;    complement factor H;    complement factor I gene;   

DOI  :  10.3389/fmed.2020.621609

来源: Frontiers

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