The Effect of Negative Pressure in the Abdominal Cavity With Suprasorb CNP on Abdominal Organs—An Experimental Study

Frontiers in Surgery

Iris Wiederstein-Grasser¹  Siegfried Sauseng²  Thomas Auer²  Pavle Delcev²  Karl H. Preisegger³ 

[1] Biomedical Research Institute, Medical University of Graz, Graz, Austria;General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Graz, Austria;Institute of Morphological Analytics and Human Genetics Graz, Graz, Austria;

关键词: negative pressure;    open abdominal therapy;    Suprasorb CNP;    porcine model;    fistula;   

DOI  :  10.3389/fsurg.2020.584926

来源: Frontiers

【 摘 要 】

Since the introduction of negative pressure therapy of the abdomen, care has been taken to protect the intestine from the effects of negative pressure in order to avoid impairments of abdominal organs. As an alternative to the widespread AB-TheraR system (KCI, San Antonio, Texas, USA), the different concept of Suprasorb CNPR (Lohmann & Rauscher, Austria-Germany) was introduced by the producer with the premise of achieving a better therapeutic effect. Due to numerous pores of the film, the effects of the negative pressure are brought to the surface of the intestinal organs and these effects were tested on seven experimental animals. Particular attention was paid to the small intestine, colon, liver, and pancreas. Over 8 h continuously, three animals were tested with −80 mmHg, 4 with −60 mmHg. The results showed no macroscopic pathological changes. The histological results showed borderline changes in the small intestine and colon with −80 mmHg application, minimal or none with −60 mmHg. The liver and pancreas were found free of pathological changes. For use on human organs, the intra-abdominal application of −60 mmHg for the Suprasorb CNP system is proposed as the standard.

【 授权许可】

CC BY