Endothelin-1 Upregulates Activin Receptor-Like Kinase-1 Expression via Gi/RhoA/Sp-1/Rho Kinase Pathways in Human Pulmonary Arterial Endothelial Cells

Frontiers in Cardiovascular Medicine

Takashi Kaneshiro¹  Kazuhiko Nakazato¹  Yasuchika Takeishi¹  Tomofumi Misaka¹  Akiomi Yoshihisa¹  Shinya Yamada¹  Koichi Sugimoto²  Tetsuro Yokokawa² 

[1] Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan;Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan;Department of Pulmonary Hypertension, Fukushima Medical University, Fukushima, Japan;

关键词: pulmonary hypertension;    small GTP protein;    endothelin;    ACVRL-1;    pulmonary endothelial cells;   

DOI  :  10.3389/fcvm.2021.648981

来源: Frontiers

【 授权许可】

CC BY