Acute Kidney Injury and Pediatric Bone Health

Frontiers in Pediatrics

Anisha Hegde¹  Michelle R. Denburg²  Dorey A. Glenn³ 

[1] Department of Pediatrics, University of North Carolina Hospitals, Chapel Hill, NC, United States;Division of Nephrology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Division of Nephrology, University of North Carolina School of Medicine, Chapel Hill, NC, United States;

关键词: AKI;    skeleton;    parathyroid hormone;    fibroblast growth factor 23;    klotho;    vitamin D;    mineral;    inflammation;   

DOI  :  10.3389/fped.2020.635628

来源: Frontiers

【 摘 要 】

Acute kidney injury (AKI) has been associated with deleterious impacts on a variety of body systems. While AKI is often accompanied by dysregulation of mineral metabolism—including alterations in calcium, phosphate, vitamin D, parathyroid hormone, fibroblast growth factor 23, and klotho—its direct effects on the skeletal system of children and adolescents remain largely unexplored. In this review, the pathophysiology of dysregulated mineral metabolism in AKI and its potential effects on skeletal health are discussed, including data associating AKI with fracture risk.

【 授权许可】

CC BY