Toward the Establishment of New Clinical Endpoints for Cystic Fibrosis: The Role of Lung Clearance Index and Cardiopulmonary Exercise Testing

Frontiers in Pediatrics

Elisavet-Anna Chrysochoou¹  Asterios Kampouras¹  Fotios Kirvassilis¹  Vasiliki Avramidou¹  Maria Galogavrou¹  Ilektra Toulia¹  John Tsanakas¹  Elpis Hatziagorou² 

[1] Pediatric Pulmonology and Cystic Fibrosis Unit, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;null;

关键词: lung clearance index (LCI);    cardiopulmonary exercise testing (CPET);    endpoints;    cystic fibrosis;    disease severity;    disease progression;   

DOI  :  10.3389/fped.2021.635719

来源: Frontiers

【 摘 要 】

As Cystic Fibrosis (CF) treatment advances, research evidence has highlighted the value and applicability of Lung Clearance Index and Cardiopulmonary Exercise Testing as endpoints for clinical trials. In the context of these new endpoints for CF trials, we have explored the use of these two test outcomes for routine CF care. In this review we have presented the use of these methods in assessing disease severity, disease progression, and the efficacy of new interventions with considerations for future research.

【 授权许可】

CC BY