Unsupervised Clustering Reveals Sarcoidosis Phenotypes Marked by a Reduction in Lymphocytes Relate to Increased Inflammatory Activity on 18FDG-PET/CT

Frontiers in Medicine

Robert P. Baughman¹  Benjamin Levin²  Yang Lu³  David L. Perkins⁴  Dustin R. Fraidenburg⁵  Christen Vagts⁵  Patricia W. Finn⁵  Yue Huang⁵  Russell Edafetanure-Ibeh⁵  Christian Ascoli⁵  Nadera J. Sweiss⁶  Samreen Ahmed⁷ 

[1] Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United States;Division of Cardiology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Jesse Brown VA Medical Center, Chicago, IL, United States;Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Division of Rheumatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Division of Rheumatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States;

关键词: sarcoidosis;    lymphopenia;    18FDG-PET/CT;    immunopathogenesis;    cluster analysis;    phenotype;   

DOI  :  10.3389/fmed.2021.595077

来源: Frontiers

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