Early body weight loss during concurrent chemo‐radiotherapy for non‐small cell lung cancer

Journal of Cachexia, Sarcopenia and Muscle

Op den Kamp Céline M. H.¹  De Ruysscher Dirk K. M.⁵  van den Heuvel Marieke¹  Elferink Meike¹  Houben Ruud M. A.⁵  Oberije Cary J. G.⁵  Bootsma Gerben P.³  Geraedts Wiel H.⁴  Pitz Cordula C. M.²  Langen Ramon C.¹  Wouters Emiel F. M.¹  Schols Annemie M. W. J.¹ 

[1] Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology & Metabolism, Maastricht University Medical Centre+, Maastricht;Department of Respiratory Medicine, Laurentius Hospital, Roermond;Department of Respiratory Medicine, Atrium Medical Centre, Heerlen;Department of Respiratory Medicine, Orbis Medical Centre, Sittard;Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Centre, GROW Research Institute, Maastricht

关键词: Weight loss;    Chemotherapy;    Concurrent;    Esophagitis;    Non‐small cell lung cancer;    Radiotherapy;   

DOI  :  10.1007/s13539-013-0127-5

来源: Wiley

【 摘 要 】

Abstract

Background and purpose

Radiation-esophagitis and weight loss are fre.uently observed toxicities in patients treated with concurrent chemo-radiotherapy (CT-RT) for non-small cell lung cancer (NSCLC) and might be related. The purpose was to investigate whether weight loss already starts early after initiation of CT-RT and precedes radiation-esophagitis.

Materials and methods

In a retrospective cohort, weight and esophagitis grade ≥2 were assessed during the first weeks of (CT-)RT in patients treated with concurrent (n = 102) or sequential (n = 92) therapy. In a prospective validation study, data on body weight, esophagitis grade ≥2, nutritional intake and muscle strength were obtained before, during and following CT-RT.

Results

In the retrospective cohort, early weight loss was observed in concurrently treated patients (p = 0.002), independent of esophagitis ≥ grade 2. Early weight loss was also observed in the prospective cohort (p = 0.003) and was not accompanied by decreases in nutritional intake. In addition lower limb muscle strength rapidly declined (p = 0.042). In the later weeks of treatment, further body weight loss occurred (p < 0.001) despite increased nutritional supplementation and body weight was only partly recovered after 4 weeks post CT-RT (p = 0.003).

Conclusions

Weight loss during concurrent CT-RT for NSCLC starts early and prior to onset of esophagitis, re.uiring timely and intense nutritional rehabilitation.

Electronic supplementary material

The online version of this article (doi:10.1007/s13539-013-0127-5) contains supplementary material.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.