Association of a 7‐year percent change in fat mass and muscle mass with subsequent cognitive dysfunction: the EPIDOS‐Toulouse cohort

Journal of Cachexia, Sarcopenia and Muscle

Abellan van Kan Gabor¹  Cesari Matteo¹  Gillette-Guyonnet Sophie¹  Dupuy Charlotte¹  Vellas Bruno¹ 

[1] Gérontopôle de Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse

关键词: Body composition;    Fat mass;    Muscle mass;    Cognitive decline;    Old age;   

DOI  :  10.1007/s13539-013-0112-z

来源: Wiley

【 摘 要 】

Abstract

Background

Cognitive dysfunction and changes in body composition share common pathophysiological pathways. The aim of the present paper was to evaluate whether changes in appendicular muscle mass (AMM) and fat mass (FM) are associated factors with an increased risk of cognitive dysfunction in community-dwelling older women.

Methods

A nested case–control study was performed in 181 women aged 75 years and older from a subsample of the Epidemiologie de l'Osteoporose participants from Toulouse. Body composition parameters at inclusion and 7 years later (assessed by dual energy X-ray absorptiometry), and the presence of cognitive dysfunction (dementia and mild cognitive impairment) at 7 years of follow-up, assured by two memory experts based on best clinical practice and validated criteria, were obtained. Multivariate logistic regression models assessed the association of percent change in AMM and FM with risk of cognitive dysfunction.

Results

At 7 years of follow-up, 15 participants suffered from dementia, 6 suffered from mild cognitive impairment, and 160 were cognitively normal. Neither body composition changes nor gait speed was found to be statistically associated with cognitive dysfunction after controlling for potential confounders. Only age, over 85 years, was associated with an increased risk of subsequent cognitive impairment (odds ratio 3.10; 95 % confidence interval 1.07–8.87).

Conclusions

No significant association could be evidenced between changes in body composition and cognitive dysfunction. Due to the small sample size, statistical power could be an issue. The study could also suggest the possibility that the risk of cognitive dysfunction is not mediated by changes in body composition.

【 授权许可】

CC BY-NC   
© 2013 The Authors. Published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.